For patients on anticoagulation therapy, what factor significantly increases the risk of bleeding complications?

Age over 75 significantly increases the risk of bleeding complications for patients on anticoagulation therapy. As individuals age, various physiological changes occur, including alterations in renal function, hemostasis, and pharmacokinetics of medications. Older patients often have a higher prevalence of comorbidities and may be taking multiple medications, which can increase the likelihood of adverse effects, including bleeding. Additionally, higher susceptibility to falls and injuries can further increase the risk of bleeding in this population.

While factors such as a history of diabetes, undergoing minor surgical procedures, and high cholesterol levels can contribute to overall health risks, they do not have the same established direct correlation with increased bleeding risk in the context of anticoagulation as age does.