What is a common adverse effect associated with the prostacyclin class of medications?

The prostacyclin class of medications, which includes agents like epoprostenol and iloprost, is primarily used for conditions such as pulmonary arterial hypertension and to improve exercise ability. A well-documented adverse effect associated with these medications is jaw pain. This side effect is often reported by patients, especially due to the direct effects of prostacyclin on the oral and mandibular regions.

Prostacyclin agents can cause vasodilation throughout the body, which may lead to discomfort in various areas, including the jaw. Patients may experience jaw pain along with other common side effects such as headaches, flushing, or gastrointestinal symptoms. These side effects can sometimes be attributed to the overall systemic effects of prostacyclin in reducing vascular resistance as part of their therapeutic action.

While transaminitis, vision changes, and teratogenicity are important factors to consider in pharmacotherapy, they are not characteristically tied to the prostacyclin class. Transaminitis often relates to hepatotoxic medications. Vision changes might be more closely associated with other classes of drugs, such as phosphodiesterase type 5 inhibitors, and teratogenic effects would be more relevant for agents with known risks in pregnancy rather than prostacyclins. Thus, jaw pain stands