What is the best treatment for knee pain in a patient with CV disease after diclofenac therapy is discontinued?

In patients with cardiovascular disease, it is crucial to choose pain relief options that minimize the risk of cardiovascular events. After diclofenac therapy is discontinued, acetaminophen is considered the best treatment for knee pain.

Acetaminophen is not a non-steroidal anti-inflammatory drug (NSAID) and does not have the same cardiovascular risks associated with other pain relief medications, such as celecoxib, meloxicam, or naproxen. Unlike these NSAIDs, which can lead to increased blood pressure, fluid retention, and potential adverse cardiovascular outcomes, acetaminophen provides pain relief without these risks.

This makes acetaminophen especially suitable for patients with a history of cardiovascular issues, ensuring pain management while maintaining a focus on safety. Additionally, it is generally well-tolerated and has a favorable safety profile when used at recommended doses. This careful consideration is essential in managing patients with cardiovascular disease and chronic pain.