What is the goal LDL-C reduction for patients at very high risk of ASCVD events receiving statin therapy?

The goal for patients at very high risk of atherosclerotic cardiovascular disease (ASCVD) events receiving statin therapy is to achieve a significant reduction in low-density lipoprotein cholesterol (LDL-C) levels, specifically aiming for a 50% reduction from baseline levels. This approach is based on clinical guidelines that respond to the understanding that high LDL-C levels are a significant contributor to cardiovascular risk. The statin therapy targets not only lowering LDL-C levels but also the reduction percentage plays a crucial role in optimizing the therapy's effectiveness.

For patients categorized as very high risk—such as those with established cardiovascular disease, diabetes, or multiple risk factors—achieving at least a 50% reduction in LDL-C provides a more tailored and aggressive cardiovascular risk management strategy. It reflects a shift from merely achieving arbitrary LDL-C numerical targets to focusing on substantial percentage reductions that have been associated with better clinical outcomes. Thus, aiming for this percentage reduction supports improved prevention of ASCVD events in these high-risk populations.