What is the maximum dose of alteplase that can be administered for thrombolysis in an acute ischemic stroke?

The maximum dose of alteplase that can be administered for thrombolysis in acute ischemic stroke is 90 mg. This is based on the guidelines established for the treatment of acute ischemic stroke, which recommend a dose of 0.9 mg/kg, with a maximum dose capped at 90 mg. This dosing strategy is designed to balance efficacy with safety, particularly to minimize the risk of adverse effects such as bleeding.

When administering alteplase, 10% of the total dose is given as an initial bolus over one minute, and the remainder is infused over the next 60 minutes. The total maximum dose of 90 mg is important to adhere to in order to optimize the therapeutic outcomes while minimizing potential complications. Other dosages presented do not align with the guidelines set forth by professional organizations, reinforcing the importance of ensuring the maximum dose for achieving effective thrombolysis in this clinical scenario.