What medication could potentially cause rebound hypertension after surgical withdrawal?

Rebound hypertension is a physiological response that can occur after the abrupt discontinuation of certain antihypertensive medications. In this context, metoprolol tartrate, a beta-blocker, is particularly relevant. When beta-blockers are abruptly withdrawn, especially in patients who have been on long-term therapy, there can be a rebound effect characterized by a significant increase in blood pressure, a condition often exacerbated by heightened adrenergic tone as the body compensates for the sudden removal of the medication's effects.

Metoprolol works by blocking the beta-adrenergic receptors, thereby reducing heart rate and myocardial contractility, which helps to lower blood pressure. When the drug is stopped suddenly, there can be an upregulation of beta-receptors and increased circulating catecholamines, leading to a surge in blood pressure. This is particularly critical for patients with pre-existing hypertension or cardiovascular disease, as the abrupt change can lead to cardiovascular complications.

In contrast, other medications mentioned, like amlodipine (a calcium channel blocker), lisinopril (an ACE inhibitor), and doxazosin (an alpha-blocker), do not typically cause rebound hypertension when withdrawn. Amlodipine and lisinopril do not