What treatment option should be added to reduce TG levels in a patient with a history of acute pancreatitis and TG concentration exceeding 1000 mg/dL?

Adding omega-3 fatty acids is particularly effective in addressing elevated triglyceride (TG) levels, especially in patients with a history of acute pancreatitis and TG concentrations exceeding 1000 mg/dL. Omega-3 fatty acids reduce hepatic production of triglycerides by decreasing the synthesis of very-low-density lipoprotein (VLDL), which is beneficial in lowering overall TG levels.

This treatment option is specifically recommended as it has been shown to significantly lower triglyceride levels and can also provide additional cardiovascular benefits. In patients with a history of pancreatitis, managing high triglyceride levels is critical to prevent further episodes, and omega-3 fatty acids have a well-established safety profile in this context.

While niacin, fibrates, and increased statin doses can also have effects on lipid levels, they may not be the most suitable first-line options in the scenario described. Niacin may increase the risk of side effects and is not typically favored when triglyceride levels are extremely high. Fibrates can also be effective, but their use must be approached with caution as they may have an increased risk of pancreatitis if not properly monitored. Statins are primarily effective for lowering LDL cholesterol rather than TG levels significantly, and increasing the dose may not adequately address