Which approach assists in recognizing a potential adverse drug event related to abrupt medication changes?

Recognizing potential adverse drug events, particularly in the context of abrupt medication changes, can be significantly enhanced by assessing trigger orders for known antidotes. This approach is effective because the presence of certain antidote orders can indicate that a medication was either inadvertently prescribed, adjusted, or discontinued without appropriate monitoring. When a healthcare provider initiates an order for an antidote, it often serves as a clue that an adverse reaction or toxicity may have occurred due to recent alterations in a patient's medication regimen.

In essence, monitoring for specific antidotes can provide direct insight into the consequences of abrupt medication changes, allowing for timely recognition and intervention to safeguard patient safety. This proactive approach is critical in preventing and managing complications that arise from medication mismanagement, thereby leading to improved patient outcomes.

The other options, while relevant, do not directly target the identification of adverse effects following abrupt changes. Patient self-reporting may lack reliability in the context of complex medication regimens, monitoring for laboratory abnormalities is more reactive rather than proactive, and simply reviewing medication reconciliation documents may not provide real-time insights into potential adverse events linked with sudden modifications in therapy.