Which drug is most likely to interact with treprostinil due to its antiplatelet effects?

Treprostinil is a vasodilator used primarily in the treatment of pulmonary arterial hypertension and has some antiplatelet effects. When considering potential drug interactions, it is important to focus on medications that also have antiplatelet properties, which can amplify the effects of treprostinil and increase the risk of bleeding.

Warfarin is an anticoagulant that works by inhibiting vitamin K-dependent clotting factors, which results in altered blood coagulation pathways. Given that both treprostinil and warfarin have the potential to impact platelet function and overall hemostasis, their concurrent use heightens the risk of bleeding complications, making the interaction particularly significant.

The other medications listed do not have similar antiplatelet effects. Glyburide is an oral antidiabetic medication that primarily lowers blood glucose levels by stimulating insulin release. Cyclosporine is an immunosuppressant and does not have antiplatelet activity. Albuterol is a bronchodilator used in asthma management and does not exert any antiplatelet effects.

Therefore, the presence of interactions between treprostinil and warfarin, due to their antiplatelet properties and effects on coagulation, underscores why warfarin is the