Which oral diuretic regimen is approximately equipotent to intravenous furosemide 40 mg twice daily?

The equivalency between oral and intravenous diuretics is an important consideration in clinical practice, particularly when managing patients who may require adjustments in their diuretic therapy. Furosemide, whether administrated orally or intravenously, has a specific potency and biological availability that needs to be accounted for when making therapeutic decisions.

When considering the choice of torsemide as an oral diuretic regimen, its oral bioavailability is notably higher than that of furosemide. Torsemide is approximately 80-100% bioavailable when taken orally, compared to furosemide's oral bioavailability, which ranges from 10-100%, depending on factors like the individual's health and gastrointestinal absorption. Therefore, when comparing an oral torsemide dosage of 40 mg with an intravenous furosemide dosage of 40 mg, torsemide offers a significant diuretic effect, making it an appropriate choice in this context.

For the specific comparison to intravenous furosemide 40 mg administered twice daily, a single oral dose of 40 mg of torsemide taken once daily is pharmacologically equipotent to that regimen due to its effective dosing and consistent bioavailability. This allows for maintaining similar diuretic effects without needing